Role of p53 in cAMP/PKA pathway mediated apoptosis
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چکیده
منابع مشابه
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Sodium orthovanadate (vanadate) inhibits the DNA-binding activity of p53, but its precise effects on p53 function have not been examined. Here, we show that vanadate exerts a potent antiapoptotic activity through both transcription-dependent and transcription-independent mechanisms relative to other p53 inhibitors, including pifithrin (PFT) alpha. We compared the effects of vanadate to PFTalpha...
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ژورنال
عنوان ژورنال: Apoptosis
سال: 2013
ISSN: 1360-8185,1573-675X
DOI: 10.1007/s10495-013-0895-6